The Amphitheatre is just a short 25 mile drive from Amarillo.

From Amarillo, take I-27 south to exit #110 (US 87). Continue south for 3 miles and into the beautiful city of Canyon.
Turn left (east) on 4th Avenue (TX 217) and drive 15 minutes to Palo Duro Canyon State Park.

From Lubbock, take I-27 north to exit #106 (TX 217).
Turn right (east) and drive 10 minutes to Palo Duro Canyon State Park.
See the map below: